Phenolic Constituents of Galla Rhois with Hepatoprotective Effects on Tacrine- and Nitrofurantoin-Induced Cytotoxicity in Hep G2 Cells

The bioassay-guided fractionation of the MeOH extract of Galla Rhois furnished two hepatoprotective compounds, an equilibrium mixture of 3-galloyl-gallic acid and 4-galloyl-gallic acid isomers (3), 1,2,3,4,6-penta-O-galloyl-β-D-glucose (4), and two inactive phenolic compounds, gallic acid methyl est...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2005, Vol.28(11), pp.2155-2157
Hauptverfasser:	An, Ren-Bo, Oh, Hyuncheol, Kim, Youn-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Survival - drug effects Chemical and Drug Induced Liver Injury - prevention & control drug-induced cytotoxicity Drugs, Chinese Herbal - pharmacology Galla Rhois Hep G2 cell hepatoprotective Humans Magnetic Resonance Spectroscopy Nitrofurantoin - antagonists & inhibitors Nitrofurantoin - toxicity Phenols - chemistry Phenols - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Tacrine - antagonists & inhibitors Tacrine - toxicity
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Zusammenfassung:	The bioassay-guided fractionation of the MeOH extract of Galla Rhois furnished two hepatoprotective compounds, an equilibrium mixture of 3-galloyl-gallic acid and 4-galloyl-gallic acid isomers (3), 1,2,3,4,6-penta-O-galloyl-β-D-glucose (4), and two inactive phenolic compounds, gallic acid methyl ester (1) and gallic acid (2). Compounds 3 and 4 showed significant hepatoprotective effects with EC50 values of 70.39±5.4 and 29.51±0.7 μM, respectively, against tacrine-induced cytotoxicity, and 150.9±6.4 and 23.81±0.5 μM, respectively, against nitrofurantoin-induced cytotoxicity in Hep G2 cells.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.28.2155