A Synthetic Retinoid Am80 (Tamibarotene) Rescues the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm
Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurolo...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2004, Vol.27(11), pp.1887-1889 |
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| container_end_page | 1889 |
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| container_issue | 11 |
| container_start_page | 1887 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 27 |
| creator | Shudo, Koichi Kagechika, Hiroyuki Yamazaki, Noriyuki Igarashi, Masaharu Tateda, Chiaki |
| description | Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurological disorders. |
| doi_str_mv | 10.1248/bpb.27.1887 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 2004, Vol.27(11), pp.1887-1889 |
| issn | 0918-6158 1347-5215 |
| language | eng |
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| source | MEDLINE; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library; J-STAGE |
| subjects | Alzheimer's disease Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - therapeutic use Avoidance Learning - drug effects Benzazepines - administration & dosage Benzazepines - therapeutic use Benzoates - administration & dosage Benzoates - therapeutic use dementia Dose-Response Relationship, Drug Male Memory Disorders - chemically induced Memory Disorders - drug therapy Memory Disorders - psychology Nootropic Agents - administration & dosage Nootropic Agents - therapeutic use Platelet Glycoprotein GPIIb-IIIa Complex - immunology RAR-ligand Rats Rats, Wistar retinoid Retinoids - administration & dosage Retinoids - therapeutic use Scopolamine tamibarotene Tetrahydronaphthalenes - administration & dosage Tetrahydronaphthalenes - therapeutic use Time Factors Trimethylsilyl Compounds - administration & dosage Trimethylsilyl Compounds - therapeutic use |
| title | A Synthetic Retinoid Am80 (Tamibarotene) Rescues the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm |
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