A Synthetic Retinoid Am80 (Tamibarotene) Rescues the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm

Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurolo...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2004, Vol.27(11), pp.1887-1889
Hauptverfasser:	Shudo, Koichi, Kagechika, Hiroyuki, Yamazaki, Noriyuki, Igarashi, Masaharu, Tateda, Chiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - therapeutic use Avoidance Learning - drug effects Benzazepines - administration & dosage Benzazepines - therapeutic use Benzoates - administration & dosage Benzoates - therapeutic use dementia Dose-Response Relationship, Drug Male Memory Disorders - chemically induced Memory Disorders - drug therapy Memory Disorders - psychology Nootropic Agents - administration & dosage Nootropic Agents - therapeutic use Platelet Glycoprotein GPIIb-IIIa Complex - immunology RAR-ligand Rats Rats, Wistar retinoid Retinoids - administration & dosage Retinoids - therapeutic use Scopolamine tamibarotene Tetrahydronaphthalenes - administration & dosage Tetrahydronaphthalenes - therapeutic use Time Factors Trimethylsilyl Compounds - administration & dosage Trimethylsilyl Compounds - therapeutic use
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Zusammenfassung:	Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurological disorders.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.27.1887