Pharmacokinetic Study of the Digoxin-acenocoumarol Interaction in Rabbits

A study was carried out to evaluate the potential pharmacokinetic interaction between digoxin and acenocoumarol. The binding of digoxin to rabbit cardiac tissue homogenates was assessed in vitro, using the equilibrium dialysis technique. An increase in the first-order constant (p

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Bibliographische Detailangaben
Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2003, Vol.26(6), pp.813-817
Hauptverfasser:	Martin-Suarez, Ana, Atencio, Drury Rudolph, Lopez, Francisco González, Santos, María, Zarzuelo, Aránzazu, Mendez, María Eugenia, Alberca, Ignacio, Lanao, José Martínez
Format:	Artikel
Sprache:	eng
Schlagworte:	Acenocoumarol - administration & dosage Acenocoumarol - metabolism Acenocoumarol - pharmacokinetics Animals Binding, Competitive Biological and medical sciences Digoxin - administration & dosage Digoxin - metabolism Digoxin - pharmacokinetics digoxin-acenocoumarol interaction distribution volume Drug Interactions Drug Therapy, Combination equilibrium dialysis In Vitro Techniques Injections, Intravenous Injections, Subcutaneous Male Medical sciences Myocardium - metabolism Non-linear Mixed Effects Modeling (NONMEM) Nonlinear Dynamics population pharmacokinetic Rabbits Tissue Distribution
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Beschreibung
Zusammenfassung:	A study was carried out to evaluate the potential pharmacokinetic interaction between digoxin and acenocoumarol. The binding of digoxin to rabbit cardiac tissue homogenates was assessed in vitro, using the equilibrium dialysis technique. An increase in the first-order constant (p
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.26.813