Isolation of Nitrophenols from Diesel Exhaust Particles (DEP) as Vasodilatation Compounds

The compounds in diesel exhaust particles (DEP) that are responsible for vasodilatation were isolated and characterized for the first time. From benzene extract of DEP, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenl and 4-nitrophenol were isolated, and their vasodilatation activities were confirmed....

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2003, Vol.26(3), pp.394-395
Hauptverfasser:	Mori, Yoki, Kamata, Kazuyuki, Toda, Noriko, Hayashi, Hideyuki, Seki, Koh-ichi, Taneda, Shinji, Yoshino, Shin, Sakushima, Akiyo, Sakata, Masakatsu, Suzuki, Akira K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - toxicity Animals Arteries - drug effects Biological and medical sciences diesel exhaust particle Isotonic Contraction - drug effects Medical sciences nitrophenol Nitrophenols - chemistry Nitrophenols - classification Nitrophenols - isolation & purification Nitrophenols - toxicity Rats Rats, Inbred F344 vasodilatation Vasodilation - drug effects Vehicle Emissions - toxicity
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Zusammenfassung:	The compounds in diesel exhaust particles (DEP) that are responsible for vasodilatation were isolated and characterized for the first time. From benzene extract of DEP, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenl and 4-nitrophenol were isolated, and their vasodilatation activities were confirmed. 3-methyl-4-nitrophenol caused dilatation of rat thoracic artery, and the other two nitrophenols, also showed vasodilatation activities.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.26.394