Inflammatory Action of 8-Methoxypsoralen-Spermine Photoproduct (8-MOP-Spm-PGFC) and Effects of Various Drugs on Rat Paw Edema Induced by 8-MOP-Spm-PGFC

The photoproducts produced by irradiating 8-methoxypsoralen (8-MOP) in the presence of spermine (Spm) were fractionated using gel filtration chromatography (GFC) on a Sephadex G-25 column. As a result, two bands which were characterized by the effects on hyaluronidase activity were obtained. The fir...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1999/11/15, Vol.22(11), pp.1202-1206
Hauptverfasser:	SHIGEHARA, Noriko, MIYATAKA, Hideki, KAKEGAWA, Hisao, NISHIKI, Mayumi, MATSUMOTO, Hitoshi, ISOBE, Akihiko, SATOH, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	8-methoxypsoralen 8-methoxypsoralen-induced photosensitivity Biological and medical sciences edema inflammation Medical sciences photoproduct Plant poisons toxicology spermine Toxicology
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Zusammenfassung:	The photoproducts produced by irradiating 8-methoxypsoralen (8-MOP) in the presence of spermine (Spm) were fractionated using gel filtration chromatography (GFC) on a Sephadex G-25 column. As a result, two bands which were characterized by the effects on hyaluronidase activity were obtained. The first band strongly activated the hyaluronidase, but a second band did not exhibit any effect on the enzyme activity. The first and second bands contained photoproducts with molecular weights (MW)>2700 and MW
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.22.1202