Stimulation of Sarcoplasmic Reticulum Ca2+-ATPase by Gingerol Analogues

We have reported previously that [8]-gingerol increased Ca2+-ATPase activity. 1, 2)Here we synthesized gingerol related compounds (AP-004, AP-005 and AP-015) and investigated the effects of gingerols ([6]-gingerol, [8]-gingerol and [10]-gingerol) and the synthesized compounds on the Ca2+-ATPase activity of sarcoplasmic reticulum (SR). The Ca2+-ATPase activity and the Ca2+-pumping activity increased by these compounds in a concentration-dependent manner. It is probable that both the o-methoxyphenol and hydrocarbon chain in the molecule of gingerol analogues are necessary for the activation of the Ca2+-pumping ATPase activity of SR.