Analysis of Mixed Drugs by Mass Spectrometry, VIII

Although in previous paper, we reported that mass spectrum of sulpyrine(I), sodium methan sulfonate of monomethylaminoantipyrine(III), is diffcult to measure due to its non-volatility. It was found that reproducible mass spectrum of thermal degraduation products of sulpyrine was obtained by raising temperature of ionization chamber and of heated inlet-system to about 250°. The identification of sulpyrine in the various preparations, (powder, granule, tablet, and injection etc.) containing sulpyrine by examination of their mass spectra is thus possible. By comparison of mass spectra of 4 kinds of pyrazolone derivatives, fragmentation of sulpyrine was also discussed.