The Mortality and Body Weight Response of Male Wistar Rats in the Lethal X-ray Dose Range

Experiments were conducted to determine the LD50/30 of Wistar strain male rats, aged 72 to 112days, bred in National Institute of Radiological Sciences. The animals were irradiated at eight exposure levels between 600 and 900 R of X-rays at rate of 23.5 R/min. Probit analysis of mortality data yield...

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Veröffentlicht in:	J. Radiat. Res. 10: 133-8(Sep-Dec 1969) 1969-01, Vol.10 (3), p.133-138
Hauptverfasser:	Tsuchihashi, S, Enomoto, Y, Yamada, T, Nakamura, W, Eto, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BODY Body Weight - radiation effects LETHAL DOSE Male N28620 -Life Sciences-Radiation Effects on Animals- Vertebrates RADIATION DOSES RADIATION EFFECTS Radiation Injuries, Experimental - mortality RATS RATS/radiation effects on body weight and survival of, effects of dose on SURVIVAL TIME Time Factors WEIGHT WEIGHT/radiation effects on body, of rats, lethal x X RADIATION X RADIATION/effects on survival of rats, effects of dose on
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Beschreibung
Zusammenfassung:	Experiments were conducted to determine the LD50/30 of Wistar strain male rats, aged 72 to 112days, bred in National Institute of Radiological Sciences. The animals were irradiated at eight exposure levels between 600 and 900 R of X-rays at rate of 23.5 R/min. Probit analysis of mortality data yielded an LD50/30 of 761.6±31.8R. The body weight of the animals was decreased gradually after irradiation, reaching a minimum value at 4th day after the exposure. The body weight of 30-day survivors shows the second minimum value at 18-21st day after irradiation.
ISSN:	0449-3060 1349-9157
DOI:	10.1269/jrr.10.133