Effect of Whole-body X-irradiation on the Microsomal Drug-metabolizing Enzyme System in Rat Liver

Aminopyrine N-demethylase activity in rat hepatic microsomes decreased significantly after whole-body X-irradiation of 500 and 650 R. Process of the phenobarbiturate-induction of aminopyrine N-demethylase was found to be inhibited during quite an early period of the induction. Adrenalectomy caused m...

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Veröffentlicht in:	J. Radiat. Res., 10: 1-7(Mar. 1969) 10: 1-7(Mar. 1969), 1969, Vol.10 (1), p.1-7
Hauptverfasser:	Ichii, S, Yago, N, Kobayashi, S, Omata, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Animals BARBITURIC ACID Cytochromes CYTOLOGY CYTOPLASM DRUGS Enzyme Induction - radiation effects ENZYMES Enzymes - radiation effects HETEROCYCLICS LIVER Liver - enzymology Male MICROSOMES Microsomes - enzymology MICROSOMES/radiation effects on phenobarbiturate induction of aminopyrine N-demethylase in, of rat liver N28140 -Life Sciences-Radiation Effects on Biochemicals ORGANIC NITROGEN COMPOUNDS OXIDOREDUCTASES/ radiation effects on aminopyrine N-demethylase, in microsomes in rat liver PYRIMIDINES RADIATION EFFECTS Radiation Injuries, Experimental - mortality RATS RATS/radiation effects on drug-metabolizing enzyme system in liver microsomes of X RADIATION X RADIATION/effects on phenobarbiturate induction of aminopyrine N-demethylase in microsomes of rat liver
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Zusammenfassung:	Aminopyrine N-demethylase activity in rat hepatic microsomes decreased significantly after whole-body X-irradiation of 500 and 650 R. Process of the phenobarbiturate-induction of aminopyrine N-demethylase was found to be inhibited during quite an early period of the induction. Adrenalectomy caused marked decreases in the enzyme activity and cytochrome P-450 content of hepatic microsomes. Physiological significance of these and other metabolic changes was discussed in relation to the lethality of acutely irradiated animals.
ISSN:	0449-3060 1349-9157
DOI:	10.1269/jrr.10.1