Hormone replacement therapy in postmenopausal women
For many years, hormone replacement therapy (HRT) was considered an effective method of restoring the relative protection from coronary artery disease enjoyed by premenopausal women compared with men of similar age. This view has been supported by a substantial number of basic science and observatio...
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| Veröffentlicht in: | The American Journal of Surgery 2004-08, Vol.188 (2), p.136-149 |
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| creator | Staren, Edgar D Omer, Shuab |
| description | For many years, hormone replacement therapy (HRT) was considered an effective method of restoring the relative protection from coronary artery disease enjoyed by premenopausal women compared with men of similar age. This view has been supported by a substantial number of basic science and observational studies.
Results of recent randomized controlled trials have seriously challenged the concept of the protective value of HRT by showing that rather than decreasing the risk of coronary artery disease, HRT actually appears to increase it. In addition, it increases the risk for breast cancer, stroke, venous thromboembolism, and cholecystitis.
Despite some benefits such as increased bone mineral density and decreased risk of fracture and colorectal cancer, these data suggest that the risks of HRT outweigh the benefits.
HRT is no longer routinely recommended for prevention of chronic disease. We present the current scientific data, benefits, risks, and consequent clinical recommendations regarding HRT use in postmenopausal women. |
| doi_str_mv | 10.1016/j.amjsurg.2003.12.063 |
| format | Article |
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Results of recent randomized controlled trials have seriously challenged the concept of the protective value of HRT by showing that rather than decreasing the risk of coronary artery disease, HRT actually appears to increase it. In addition, it increases the risk for breast cancer, stroke, venous thromboembolism, and cholecystitis.
Despite some benefits such as increased bone mineral density and decreased risk of fracture and colorectal cancer, these data suggest that the risks of HRT outweigh the benefits.
HRT is no longer routinely recommended for prevention of chronic disease. We present the current scientific data, benefits, risks, and consequent clinical recommendations regarding HRT use in postmenopausal women.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2003.12.063</identifier><identifier>PMID: 15249239</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Breast cancer ; Breast Neoplasms - epidemiology ; C-Reactive Protein - analysis ; Cancer ; Cardiology. Vascular system ; Cardiovascular disease ; Cholecystitis - epidemiology ; Chronic Disease - epidemiology ; Coronary artery disease ; Coronary Disease - epidemiology ; Coronary heart disease ; Dermatology ; Estrogen ; Estrogen Replacement Therapy - adverse effects ; Female ; General aspects ; Heart ; Hormone replacement therapy ; Hormones. Endocrine system ; Hot flashes ; Humans ; Medical sciences ; Menopause ; Middle Aged ; Osteoporosis - prevention & control ; Pharmacology. Drug treatments ; Practice Guidelines as Topic ; Randomized Controlled Trials as Topic ; Risk Factors ; Stroke - epidemiology ; Vascular disorders of the skin ; Venous Thrombosis - epidemiology ; Women's Health ; Womens health</subject><ispartof>The American Journal of Surgery, 2004-08, Vol.188 (2), p.136-149</ispartof><rights>2004 Excerpta Medica Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Limited Aug 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-54fce1399d884f497964e158b834ab4c9feb1bc87b8ddd8b459a63b1fe28c4523</citedby><cites>FETCH-LOGICAL-c476t-54fce1399d884f497964e158b834ab4c9feb1bc87b8ddd8b459a63b1fe28c4523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1444596368?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>313,314,776,780,788,3536,27901,27903,27904,64361,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15958480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15249239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Staren, Edgar D</creatorcontrib><creatorcontrib>Omer, Shuab</creatorcontrib><title>Hormone replacement therapy in postmenopausal women</title><title>The American Journal of Surgery</title><addtitle>Am J Surg</addtitle><description>For many years, hormone replacement therapy (HRT) was considered an effective method of restoring the relative protection from coronary artery disease enjoyed by premenopausal women compared with men of similar age. This view has been supported by a substantial number of basic science and observational studies.
Results of recent randomized controlled trials have seriously challenged the concept of the protective value of HRT by showing that rather than decreasing the risk of coronary artery disease, HRT actually appears to increase it. In addition, it increases the risk for breast cancer, stroke, venous thromboembolism, and cholecystitis.
Despite some benefits such as increased bone mineral density and decreased risk of fracture and colorectal cancer, these data suggest that the risks of HRT outweigh the benefits.
HRT is no longer routinely recommended for prevention of chronic disease. We present the current scientific data, benefits, risks, and consequent clinical recommendations regarding HRT use in postmenopausal women.</description><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>C-Reactive Protein - analysis</subject><subject>Cancer</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cholecystitis - epidemiology</subject><subject>Chronic Disease - epidemiology</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary heart disease</subject><subject>Dermatology</subject><subject>Estrogen</subject><subject>Estrogen Replacement Therapy - adverse effects</subject><subject>Female</subject><subject>General aspects</subject><subject>Heart</subject><subject>Hormone replacement therapy</subject><subject>Hormones. Endocrine system</subject><subject>Hot flashes</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Osteoporosis - prevention & control</subject><subject>Pharmacology. 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Vascular system</topic><topic>Cardiovascular disease</topic><topic>Cholecystitis - epidemiology</topic><topic>Chronic Disease - epidemiology</topic><topic>Coronary artery disease</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary heart disease</topic><topic>Dermatology</topic><topic>Estrogen</topic><topic>Estrogen Replacement Therapy - adverse effects</topic><topic>Female</topic><topic>General aspects</topic><topic>Heart</topic><topic>Hormone replacement therapy</topic><topic>Hormones. Endocrine system</topic><topic>Hot flashes</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Osteoporosis - prevention & control</topic><topic>Pharmacology. Drug treatments</topic><topic>Practice Guidelines as Topic</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Risk Factors</topic><topic>Stroke - epidemiology</topic><topic>Vascular disorders of the skin</topic><topic>Venous Thrombosis - epidemiology</topic><topic>Women's Health</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Staren, Edgar D</creatorcontrib><creatorcontrib>Omer, Shuab</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>The American Journal of Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Staren, Edgar D</au><au>Omer, Shuab</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hormone replacement therapy in postmenopausal women</atitle><jtitle>The American Journal of Surgery</jtitle><addtitle>Am J Surg</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>188</volume><issue>2</issue><spage>136</spage><epage>149</epage><pages>136-149</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>For many years, hormone replacement therapy (HRT) was considered an effective method of restoring the relative protection from coronary artery disease enjoyed by premenopausal women compared with men of similar age. This view has been supported by a substantial number of basic science and observational studies.
Results of recent randomized controlled trials have seriously challenged the concept of the protective value of HRT by showing that rather than decreasing the risk of coronary artery disease, HRT actually appears to increase it. In addition, it increases the risk for breast cancer, stroke, venous thromboembolism, and cholecystitis.
Despite some benefits such as increased bone mineral density and decreased risk of fracture and colorectal cancer, these data suggest that the risks of HRT outweigh the benefits.
HRT is no longer routinely recommended for prevention of chronic disease. We present the current scientific data, benefits, risks, and consequent clinical recommendations regarding HRT use in postmenopausal women.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15249239</pmid><doi>10.1016/j.amjsurg.2003.12.063</doi><tpages>14</tpages></addata></record> |
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| subjects | Biological and medical sciences Breast cancer Breast Neoplasms - epidemiology C-Reactive Protein - analysis Cancer Cardiology. Vascular system Cardiovascular disease Cholecystitis - epidemiology Chronic Disease - epidemiology Coronary artery disease Coronary Disease - epidemiology Coronary heart disease Dermatology Estrogen Estrogen Replacement Therapy - adverse effects Female General aspects Heart Hormone replacement therapy Hormones. Endocrine system Hot flashes Humans Medical sciences Menopause Middle Aged Osteoporosis - prevention & control Pharmacology. Drug treatments Practice Guidelines as Topic Randomized Controlled Trials as Topic Risk Factors Stroke - epidemiology Vascular disorders of the skin Venous Thrombosis - epidemiology Women's Health Womens health |
| title | Hormone replacement therapy in postmenopausal women |
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