Summary of Toxicological Studies on Prodiamine

Prodiamine was considered to be a low toxic substance since its LD50 values of acute toxicity in rats and mice were over 5000mg/kg in oral test and 2000mg/kg in dermal test. Prodiamine 65WDG formulation had a “positive” response to eye in rabbits. Its technical, however, was non-irritant to eye and both of 65WDG and technical were considered to be non-irritant to skin. Prodiamine technical was considered to be a non-sensitizer. Its 65WDG formulation might be considered to be a mild sensitizer. The high dose level of prodiamine produced retarded body weight gain and minor change in the blood in subchronic dietary toxicity study. However, middle and low dose level of prodiamine produced almost no changes in the study. Prodiamine had no teratogenic potential in the studies of rats and rabbits, and no potential revealed in mutagenic studies. Prodiamine has been one of important herbicides for golf course since it registered in 1991.