Effects of Ultrasound on Bone Formation Induced by BMP-2

Low-intensity pulsed ultrasound (LIPUS) is therapeutic instrument of improving bone healing, and Bone Morphogenetic Protein-2 (BMP-2) has been demonstrated to enhance bone formation. The present study was designed to evaluate the effects of LIPUS on bone formation induced by BMP-2 at palatal subperiosteal sites in Wister rats. Alginated gel (AG) contained BMP-2 (1.0µg/µL) was implanted into the palatal left site (BMP site), and AG alone was the right site (AG site). The rats were divided into two groups; LIPUS group, ultrasound (1MHz, 160mW, 5 min) was performed every three days, and non-LIPUS group. At 3 weeks after surgery, thickness of new bone of BMP site was significantly higher than that of AG site (P