A randomized controlled trial of fresh frozen plasma for treating venom‐induced consumption coagulopathy in cases of Australian snakebite (ASP‐18)

Summary Background Venom‐induced consumption coagulopathy (VICC) is a major effect of snake envenoming. Objectives To investigate whether fresh frozen plasma (FFP) given after antivenom resulted in more rapid correction of coagulation. Patients/Methods This was a multicenter open‐label randomized controlled trial in patients with VICC of FFP vs. no FFP within 4 h of antivenom administration. Patients (> 2 years) recruited to the Australian snakebite project with VICC (International Normalized Ratio [INR] > 3) were eligible. Patients were randomized 2 : 1 to receive FFP or no FFP. The primary outcome was the proportion with an INR of