Nuclear Factor [kappa]B Inhibition by Dibenzoylmethane Derivatives

We established stable HeLa transformants with reporter genes containing nuclear factor (NF)-κB response elements to measure NF-κB inhibition. Tumor necrosis factor (TNF)-α treatment induced a 6-fold activation of NF-κB in HeLaNF-κB-3 cells. Three chloro-derivatives of fourteen dibenzoylmethane deriv...

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Veröffentlicht in:	Journal of health science (Tokyo, Japan) Japan), 2009-03, Vol.55 (2), p.311
Hauptverfasser:	Matsuura, Nobuyasu, Murakami, Rika, Katayama, Tomoyuki, Hibino, Satoshi, Choshi, Tominari, Yamada, Masashi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Zusammenfassung:	We established stable HeLa transformants with reporter genes containing nuclear factor (NF)-κB response elements to measure NF-κB inhibition. Tumor necrosis factor (TNF)-α treatment induced a 6-fold activation of NF-κB in HeLaNF-κB-3 cells. Three chloro-derivatives of fourteen dibenzoylmethane derivatives inhibited NF-κB activity.
ISSN:	1344-9702 1347-5207