Effect of Fish Oil on Myocardial Antioxidant Defense in Isoproterenol-Induced Myocardial Infarction

The effect of fish oil treatment on the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase, and on the levels of lipid peroxides and glutathione of myocardial tissue was studied in isoproterenol-induced myocardial infarction. The biochemical lesion due to the activation of lipid peroxidation and decrease in antioxidant status could be significantly implicated in the experimental myocardial infarction induced by isoproterenol. The protective effect of fish oil was achieved by decreasing the peroxide concentration and the normalization of the levels of antioxidant defense enzymes.