Pentazocine Effect on Rat Testis
Administration of pentazocine lactate (3mg/kg body weight per day) for 10 or 20 days to male rats decreased testicular weight and significantly reduced the protein, DNA, and RNA contents of the testes. Testicular lipids increased significantly after the treatment. Activities of the esterase and acid...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 1998, Vol.25(3), pp.143-148 |
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| container_title | Journal of Clinical Biochemistry and Nutrition |
| container_volume | 25 |
| creator | KAVITHA, John ARUMUGAM, Venkatesan |
| description | Administration of pentazocine lactate (3mg/kg body weight per day) for 10 or 20 days to male rats decreased testicular weight and significantly reduced the protein, DNA, and RNA contents of the testes. Testicular lipids increased significantly after the treatment. Activities of the esterase and acid phosphatase decreased significantly after pentazocine treatment, whereas the alkaline phosphatase activity was found to be elevated. The data suggest that pentazocine analgesia interferes with biochemical components and metabolic activities of the testis, which interference results in the accumulation of lipids. This is possibly due to the suppressed steroidogenesis and spermatogenesis. |
| doi_str_mv | 10.3164/jcbn.25.143 |
| format | Article |
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Testicular lipids increased significantly after the treatment. Activities of the esterase and acid phosphatase decreased significantly after pentazocine treatment, whereas the alkaline phosphatase activity was found to be elevated. The data suggest that pentazocine analgesia interferes with biochemical components and metabolic activities of the testis, which interference results in the accumulation of lipids. This is possibly due to the suppressed steroidogenesis and spermatogenesis.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.25.143</identifier><language>eng</language><publisher>Tokyo: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>addiction ; biochemistry ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Medical sciences ; pentazocine ; Pharmacology. 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Clin. Biochem. Nutr.</addtitle><description>Administration of pentazocine lactate (3mg/kg body weight per day) for 10 or 20 days to male rats decreased testicular weight and significantly reduced the protein, DNA, and RNA contents of the testes. Testicular lipids increased significantly after the treatment. Activities of the esterase and acid phosphatase decreased significantly after pentazocine treatment, whereas the alkaline phosphatase activity was found to be elevated. The data suggest that pentazocine analgesia interferes with biochemical components and metabolic activities of the testis, which interference results in the accumulation of lipids. This is possibly due to the suppressed steroidogenesis and spermatogenesis.</description><subject>addiction</subject><subject>biochemistry</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Medical sciences</subject><subject>pentazocine</subject><subject>Pharmacology. 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Drug treatments</topic><topic>rats</topic><topic>testis</topic><topic>Toxicity: urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAVITHA, John</creatorcontrib><creatorcontrib>ARUMUGAM, Venkatesan</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAVITHA, John</au><au>ARUMUGAM, Venkatesan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pentazocine Effect on Rat Testis</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. 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This is possibly due to the suppressed steroidogenesis and spermatogenesis.</abstract><cop>Tokyo</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><doi>10.3164/jcbn.25.143</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | addiction biochemistry Biological and medical sciences Drug toxicity and drugs side effects treatment Medical sciences pentazocine Pharmacology. Drug treatments rats testis Toxicity: urogenital system |
| title | Pentazocine Effect on Rat Testis |
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