Pentazocine Effect on Rat Testis

Administration of pentazocine lactate (3mg/kg body weight per day) for 10 or 20 days to male rats decreased testicular weight and significantly reduced the protein, DNA, and RNA contents of the testes. Testicular lipids increased significantly after the treatment. Activities of the esterase and acid phosphatase decreased significantly after pentazocine treatment, whereas the alkaline phosphatase activity was found to be elevated. The data suggest that pentazocine analgesia interferes with biochemical components and metabolic activities of the testis, which interference results in the accumulation of lipids. This is possibly due to the suppressed steroidogenesis and spermatogenesis.