Protective Effect of Chlorogenic Acid on Lipid Peroxidation Induced in the Liver of Rats by Carbon Tetrachloride or 60Co-Irradiation

The protective effect of chlorogenic acid, which occurs in tea leaves and coffee beans, on lipid peroxidation induced in the liver of rats by the administration of carbon tetrachloride or by 60Co-irradiation was examined. When chlorogenic acid was administered once a day for 3 successive days before the administration of carbon tetrachloride, the substance suppressed the increase in lipid peroxide level in the liver. The leakage into the bloodstream of glutamate oxaloacetate and glutamate pyruvate transaminases from the liver was also suppressed, and this finding was supported by morphological observations. When rats administered chlorogenic acid once a day for 5 successive days were irradiated with 60Co once a day for the last three days, the increase in serum and liver lipid peroxide levels was significantly suppressed as compared with the control.