Neuroanatomical Abnormalities Before the Onset of Various Types of Delusions in a Patient With Alzheimer Disease

[...]risperidone (0.5 mg/day) was prescribed for her delusions, and the delusions disappeared. Both the frontal and insular areas are thought to be linked with psychotic symptoms in AD patients.3,4 More importantly, before the onset of the delusions, the patient exhibited volume reductions in these areas. [...]the abnormalities in both the frontal areas and the insulae likely reflect a pre-existing vulnerability in the present patient with AD who developed delusions.