The metabolic responses induced by acute dexamethasone predict glucose tolerance and insulin secretion over 10years in relatives of type 2 diabetic subjects

Background This study aimed to compare the metabolic and insulin secretory responses to dexamethasone with the metabolic responses observed at 10years in normoglycaemic relatives of type 2 diabetic and healthy control subjects. Methods Twenty relatives and 20 matched control subjects were studied tw...

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Veröffentlicht in:Diabetes/metabolism research and reviews 2013-09, Vol.29 (6), p.492
Hauptverfasser: Durck, Tina Trier, Henriksen, Jan Erik, Egede, Mette Brogaard, Levin, Klaus, Rantzau, Christian, Ward, Glenn, Beck-Nielsen, Henning, Alford, Frank P
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Sprache:eng
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Zusammenfassung:Background This study aimed to compare the metabolic and insulin secretory responses to dexamethasone with the metabolic responses observed at 10years in normoglycaemic relatives of type 2 diabetic and healthy control subjects. Methods Twenty relatives and 20 matched control subjects were studied twice at 0year (pre- and post-dexamethasone) and at 10years, employing a 75-g oral glucose tolerance test (OGTT), with serial measurements of glucose and insulin, for determination of glucose tolerance and calculations of acute insulin release ([Delta]I30/[Delta]G30; insulinogenic index) and insulin sensitivity (SIHOMA). Results Following dexamethasone, the relatives group developed varying degrees of glucose intolerance, associated with reduced insulin sensitivity and insulinogenic index. By 10years, fasting glucose and 2-h OGTT glucose were raised in the relatives group, especially in the relatives most metabolically affected by dexamethasone, including a reduced insulinogenic index. Multiple regression analysis of the data in relatives demonstrated that the 2-h OGTT glucose and fasting glucose values at 10years depended on the 0-year post-dexamethasone 2-h OGTT glucose, post-dexamethasone fasting glucose and post-dexamethasone insulin sensitivity, r2adj=56% (p
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.2418