Bismuth-induced neuronal cell death in rat dorsal root ganglion: a stereological study
The goal of the present study has been to quantify the morphological changes in myelinated nerve roots and dorsal root ganglion (DRG) cells in rats exposed to bismuth subnitrate. Male Wistar rats (n =30) were divided into three groups of ten animals. The ten animals in each group were given intraper...
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| Veröffentlicht in: | Acta neuropathologica 2003-04, Vol.105 (4), p.351-357 |
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| creator | STOLTENBERG, Meredin SCHIØNNING, Jørgen D WEST, Mark J DANSCHER, Gorm |
| description | The goal of the present study has been to quantify the morphological changes in myelinated nerve roots and dorsal root ganglion (DRG) cells in rats exposed to bismuth subnitrate. Male Wistar rats (n =30) were divided into three groups of ten animals. The ten animals in each group were given intraperitoneal injections of one of the following: (1) 500 mg/kg bismuth subnitrate, (2) 1,000 mg/kg bismuth subnitrate, or (3) saline. The mean total cell number of B-cells in the DRG was significantly smaller in the two treated groups, 18% (2P |
| doi_str_mv | 10.1007/s00401-002-0650-5 |
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Male Wistar rats (n =30) were divided into three groups of ten animals. The ten animals in each group were given intraperitoneal injections of one of the following: (1) 500 mg/kg bismuth subnitrate, (2) 1,000 mg/kg bismuth subnitrate, or (3) saline. The mean total cell number of B-cells in the DRG was significantly smaller in the two treated groups, 18% (2P <0.001) and 23% (2P <0.001), respectively, than it was in the control group. In addition, there was an 11% reduction in the number of A-cells (2P =0.039) in rats exposed to the highest concentration of bismuth. Bismuth did not affect the total number or mean cross sectional area of axons and myelin sheaths of the myelinated nerve fibers in the ventral or dorsal nerve root of the DRG. This is the first study to investigate pathological changes of the peripheral nervous system after bismuth intoxication.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s00401-002-0650-5</identifier><identifier>PMID: 12624788</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Antacids - toxicity ; Biological and medical sciences ; Bismuth - toxicity ; Cell Count ; Chemical and industrial products toxicology. Toxic occupational diseases ; Dose-Response Relationship, Drug ; Drug toxicity and drugs side effects treatment ; Ganglia, Spinal - drug effects ; Ganglia, Spinal - pathology ; Male ; Medical sciences ; Metals and various inorganic compounds ; Myelin Sheath - drug effects ; Myelin Sheath - pathology ; Neurons - drug effects ; Neurons - pathology ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Rodents ; Toxicity: nervous system and muscle ; Toxicology</subject><ispartof>Acta neuropathologica, 2003-04, Vol.105 (4), p.351-357</ispartof><rights>2003 INIST-CNRS</rights><rights>Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-90e54183c56f8de178ccd87ba888a07f3e425c9ba2d83644021557907c67d2e73</citedby><cites>FETCH-LOGICAL-c355t-90e54183c56f8de178ccd87ba888a07f3e425c9ba2d83644021557907c67d2e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14580196$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12624788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STOLTENBERG, Meredin</creatorcontrib><creatorcontrib>SCHIØNNING, Jørgen D</creatorcontrib><creatorcontrib>WEST, Mark J</creatorcontrib><creatorcontrib>DANSCHER, Gorm</creatorcontrib><title>Bismuth-induced neuronal cell death in rat dorsal root ganglion: a stereological study</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>The goal of the present study has been to quantify the morphological changes in myelinated nerve roots and dorsal root ganglion (DRG) cells in rats exposed to bismuth subnitrate. Male Wistar rats (n =30) were divided into three groups of ten animals. The ten animals in each group were given intraperitoneal injections of one of the following: (1) 500 mg/kg bismuth subnitrate, (2) 1,000 mg/kg bismuth subnitrate, or (3) saline. The mean total cell number of B-cells in the DRG was significantly smaller in the two treated groups, 18% (2P <0.001) and 23% (2P <0.001), respectively, than it was in the control group. In addition, there was an 11% reduction in the number of A-cells (2P =0.039) in rats exposed to the highest concentration of bismuth. Bismuth did not affect the total number or mean cross sectional area of axons and myelin sheaths of the myelinated nerve fibers in the ventral or dorsal nerve root of the DRG. This is the first study to investigate pathological changes of the peripheral nervous system after bismuth intoxication.</description><subject>Animals</subject><subject>Antacids - toxicity</subject><subject>Biological and medical sciences</subject><subject>Bismuth - toxicity</subject><subject>Cell Count</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Ganglia, Spinal - drug effects</subject><subject>Ganglia, Spinal - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Myelin Sheath - drug effects</subject><subject>Myelin Sheath - pathology</subject><subject>Neurons - drug effects</subject><subject>Neurons - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Toxicity: nervous system and muscle</subject><subject>Toxicology</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpFkE1LAzEQhoMotlZ_gBcJiMfVydcm602LX1Dwol5DmmTbLduNJruH_ntTutDTMLzPDDMPQtcE7gmAfEgAHEgBQAsoBRTiBE0JZ7kTjJ2iKUBOS0bpBF2ktMkdlVycowmhJeVSqSn6eW7SdujXRdO5wXqHOz_E0JkWW9-22HnTr3HT4Wh67EJMOYgh9HhlulXbhO4RG5x6H31ow6qxOU794HaX6Kw2bfJXY52h79eXr_l7sfh8-5g_LQrLhOiLCrzgRDErylo5T6Sy1im5NEopA7JmnlNhq6WhTrGSc6BECFmBtKV01Es2Q7eHvb8x_A0-9XoThpjPT5pwqggFQlimyIGyMaQUfa1_Y7M1cacJ6L1JfTCps0m9N6lFnrkZNw_LrXfHiVFdBu5GwKT8dx1NZ5t05LhQQKqS_QNrwXo9</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>STOLTENBERG, Meredin</creator><creator>SCHIØNNING, Jørgen D</creator><creator>WEST, Mark J</creator><creator>DANSCHER, Gorm</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20030401</creationdate><title>Bismuth-induced neuronal cell death in rat dorsal root ganglion: a stereological study</title><author>STOLTENBERG, Meredin ; SCHIØNNING, Jørgen D ; WEST, Mark J ; DANSCHER, Gorm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-90e54183c56f8de178ccd87ba888a07f3e425c9ba2d83644021557907c67d2e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antacids - toxicity</topic><topic>Biological and medical sciences</topic><topic>Bismuth - toxicity</topic><topic>Cell Count</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Ganglia, Spinal - drug effects</topic><topic>Ganglia, Spinal - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Myelin Sheath - drug effects</topic><topic>Myelin Sheath - pathology</topic><topic>Neurons - drug effects</topic><topic>Neurons - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Toxicity: nervous system and muscle</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STOLTENBERG, Meredin</creatorcontrib><creatorcontrib>SCHIØNNING, Jørgen D</creatorcontrib><creatorcontrib>WEST, Mark J</creatorcontrib><creatorcontrib>DANSCHER, Gorm</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STOLTENBERG, Meredin</au><au>SCHIØNNING, Jørgen D</au><au>WEST, Mark J</au><au>DANSCHER, Gorm</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bismuth-induced neuronal cell death in rat dorsal root ganglion: a stereological study</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>105</volume><issue>4</issue><spage>351</spage><epage>357</epage><pages>351-357</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>The goal of the present study has been to quantify the morphological changes in myelinated nerve roots and dorsal root ganglion (DRG) cells in rats exposed to bismuth subnitrate. Male Wistar rats (n =30) were divided into three groups of ten animals. The ten animals in each group were given intraperitoneal injections of one of the following: (1) 500 mg/kg bismuth subnitrate, (2) 1,000 mg/kg bismuth subnitrate, or (3) saline. The mean total cell number of B-cells in the DRG was significantly smaller in the two treated groups, 18% (2P <0.001) and 23% (2P <0.001), respectively, than it was in the control group. In addition, there was an 11% reduction in the number of A-cells (2P =0.039) in rats exposed to the highest concentration of bismuth. Bismuth did not affect the total number or mean cross sectional area of axons and myelin sheaths of the myelinated nerve fibers in the ventral or dorsal nerve root of the DRG. This is the first study to investigate pathological changes of the peripheral nervous system after bismuth intoxication.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12624788</pmid><doi>10.1007/s00401-002-0650-5</doi><tpages>7</tpages></addata></record> |
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| ispartof | Acta neuropathologica, 2003-04, Vol.105 (4), p.351-357 |
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| subjects | Animals Antacids - toxicity Biological and medical sciences Bismuth - toxicity Cell Count Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Ganglia, Spinal - drug effects Ganglia, Spinal - pathology Male Medical sciences Metals and various inorganic compounds Myelin Sheath - drug effects Myelin Sheath - pathology Neurons - drug effects Neurons - pathology Pharmacology. Drug treatments Rats Rats, Wistar Rodents Toxicity: nervous system and muscle Toxicology |
| title | Bismuth-induced neuronal cell death in rat dorsal root ganglion: a stereological study |
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