Bismuth-induced neuronal cell death in rat dorsal root ganglion: a stereological study

The goal of the present study has been to quantify the morphological changes in myelinated nerve roots and dorsal root ganglion (DRG) cells in rats exposed to bismuth subnitrate. Male Wistar rats (n =30) were divided into three groups of ten animals. The ten animals in each group were given intraper...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta neuropathologica 2003-04, Vol.105 (4), p.351-357
Hauptverfasser:	STOLTENBERG, Meredin, SCHIØNNING, Jørgen D, WEST, Mark J, DANSCHER, Gorm
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antacids - toxicity Biological and medical sciences Bismuth - toxicity Cell Count Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Ganglia, Spinal - drug effects Ganglia, Spinal - pathology Male Medical sciences Metals and various inorganic compounds Myelin Sheath - drug effects Myelin Sheath - pathology Neurons - drug effects Neurons - pathology Pharmacology. Drug treatments Rats Rats, Wistar Rodents Toxicity: nervous system and muscle Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The goal of the present study has been to quantify the morphological changes in myelinated nerve roots and dorsal root ganglion (DRG) cells in rats exposed to bismuth subnitrate. Male Wistar rats (n =30) were divided into three groups of ten animals. The ten animals in each group were given intraperitoneal injections of one of the following: (1) 500 mg/kg bismuth subnitrate, (2) 1,000 mg/kg bismuth subnitrate, or (3) saline. The mean total cell number of B-cells in the DRG was significantly smaller in the two treated groups, 18% (2P
ISSN:	0001-6322 1432-0533
DOI:	10.1007/s00401-002-0650-5