Assessing tablet-sticking propensity

Assessing tablet-sticking propensity

The effect of tableting lubricant was studied for blends containing either Ibuprofen or spray-dried mannitol with various levels of magnesium stéarate, As expected from tableting experience, the spray-dried mannitol had a lower absolute sticking propensity relative to Ibuprofen. But, interestingly,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutical technology Europe 2012-01, Vol.24 (1), p.31
Hauptverfasser: Mullarney, Matthew P, MacDonald, Bruce C, Hutchins, Allan
Format: Artikel
Sprache:eng
Schlagworte:
Cellulose
Drug delivery systems
Magnesium
Manufacturing
Nonsteroidal anti-inflammatory drugs
Pharmaceuticals
Product design
Production methods
Studies
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The effect of tableting lubricant was studied for blends containing either Ibuprofen or spray-dried mannitol with various levels of magnesium stéarate, As expected from tableting experience, the spray-dried mannitol had a lower absolute sticking propensity relative to Ibuprofen. But, interestingly, opposite trends were observed for the mannitol versus the Ibuprofen formulations with various lubricant levels.
ISSN:1753-7967