The use of diffuse laser photonic energy and indocyanine green photosensitiser as an adjunct to periodontal therapy

Key Points Explores anti-bacterial photodynamic therapy as an adjunct to other periodontal treatment therapies. Outlines how indocyanine green photosensitiser may be activated using a diode laser wavelength (810 nm) to provide generalised bacteriocidal effect. Describes how this treatment provides a...

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Veröffentlicht in:British dental journal 2013-08, Vol.215 (4), p.167-171
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description Key Points Explores anti-bacterial photodynamic therapy as an adjunct to other periodontal treatment therapies. Outlines how indocyanine green photosensitiser may be activated using a diode laser wavelength (810 nm) to provide generalised bacteriocidal effect. Describes how this treatment provides antibacterial action to augment scaling and root planing, as well as in open flap periodontal surgery. Light-activated chemical therapy – generally known as photodynamic therapy (PDT) – has been developed within medicine, to allow the use of an applied agent (photosensitiser) that could be activated using laser photonic energy, leading to the destruction of target cellular structures. In clinical dentistry, PDT has been utilised within a wide scope of topical application in endodontic, periodontal and oral epithelial pathology where specifically, anti-bacterial action may prove useful. Underlying the complex and multi-factorial aetiology, periodontal disease remains of essentially-bacterial origin and anti-bacterial PDT (aPDT) has been investigated as an adjunctive to other periodontal treatment therapies. Of several topically-applied photosensitisers, one agent, indocyanine green, may be activated using a diode laser wavelength (810 nm) that is commonly-available in clinical dental practice, to provide generalised bacteriocidal effect. Unlike antibiotics and antibacterial mouthwashes, the mode of action appears to be nonspecific to bacterial species and is linked to cell death through a process of oxidative stress. Additionally, indocyanine green has otherwise low toxicity to non-target host tissue and dental restorative materials. This paper explores the background to this therapy, its position within the broader delivery of periodontal treatment and the specific application of indocyanine green in clinical dental practice.
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source MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals
subjects 639/301/930
692/700/565
Ablation
Alveolar Bone Loss - drug therapy
Alveolar Bone Loss - surgery
Bone Substitutes - therapeutic use
Combined Modality Therapy
Dental Fistula - drug therapy
Dental Fistula - surgery
Dentistry
Energy
Energy Transfer
Humans
Indocyanine Green - therapeutic use
Lasers
Lasers, Semiconductor - therapeutic use
Light
Low-Level Light Therapy - instrumentation
Low-Level Light Therapy - methods
Medicine
Oxidative stress
Oxidative Stress - physiology
Periodontal Diseases - drug therapy
Periodontal Diseases - microbiology
Periodontal Pocket - drug therapy
Periodontal Pocket - microbiology
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - therapeutic use
practice
Reactive Oxygen Species - therapeutic use
Surgical Flaps - surgery
Tissues
Toxicity
title The use of diffuse laser photonic energy and indocyanine green photosensitiser as an adjunct to periodontal therapy
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