The use of diffuse laser photonic energy and indocyanine green photosensitiser as an adjunct to periodontal therapy
Key Points Explores anti-bacterial photodynamic therapy as an adjunct to other periodontal treatment therapies. Outlines how indocyanine green photosensitiser may be activated using a diode laser wavelength (810 nm) to provide generalised bacteriocidal effect. Describes how this treatment provides a...
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description | Key Points
Explores anti-bacterial photodynamic therapy as an adjunct to other periodontal treatment therapies.
Outlines how indocyanine green photosensitiser may be activated using a diode laser wavelength (810 nm) to provide generalised bacteriocidal effect.
Describes how this treatment provides antibacterial action to augment scaling and root planing, as well as in open flap periodontal surgery.
Light-activated chemical therapy – generally known as photodynamic therapy (PDT) – has been developed within medicine, to allow the use of an applied agent (photosensitiser) that could be activated using laser photonic energy, leading to the destruction of target cellular structures. In clinical dentistry, PDT has been utilised within a wide scope of topical application in endodontic, periodontal and oral epithelial pathology where specifically, anti-bacterial action may prove useful. Underlying the complex and multi-factorial aetiology, periodontal disease remains of essentially-bacterial origin and anti-bacterial PDT (aPDT) has been investigated as an adjunctive to other periodontal treatment therapies. Of several topically-applied photosensitisers, one agent, indocyanine green, may be activated using a diode laser wavelength (810 nm) that is commonly-available in clinical dental practice, to provide generalised bacteriocidal effect. Unlike antibiotics and antibacterial mouthwashes, the mode of action appears to be nonspecific to bacterial species and is linked to cell death through a process of oxidative stress. Additionally, indocyanine green has otherwise low toxicity to non-target host tissue and dental restorative materials. This paper explores the background to this therapy, its position within the broader delivery of periodontal treatment and the specific application of indocyanine green in clinical dental practice. |
doi_str_mv | 10.1038/sj.bdj.2013.790 |
format | Article |
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Explores anti-bacterial photodynamic therapy as an adjunct to other periodontal treatment therapies.
Outlines how indocyanine green photosensitiser may be activated using a diode laser wavelength (810 nm) to provide generalised bacteriocidal effect.
Describes how this treatment provides antibacterial action to augment scaling and root planing, as well as in open flap periodontal surgery.
Light-activated chemical therapy – generally known as photodynamic therapy (PDT) – has been developed within medicine, to allow the use of an applied agent (photosensitiser) that could be activated using laser photonic energy, leading to the destruction of target cellular structures. In clinical dentistry, PDT has been utilised within a wide scope of topical application in endodontic, periodontal and oral epithelial pathology where specifically, anti-bacterial action may prove useful. Underlying the complex and multi-factorial aetiology, periodontal disease remains of essentially-bacterial origin and anti-bacterial PDT (aPDT) has been investigated as an adjunctive to other periodontal treatment therapies. Of several topically-applied photosensitisers, one agent, indocyanine green, may be activated using a diode laser wavelength (810 nm) that is commonly-available in clinical dental practice, to provide generalised bacteriocidal effect. Unlike antibiotics and antibacterial mouthwashes, the mode of action appears to be nonspecific to bacterial species and is linked to cell death through a process of oxidative stress. Additionally, indocyanine green has otherwise low toxicity to non-target host tissue and dental restorative materials. This paper explores the background to this therapy, its position within the broader delivery of periodontal treatment and the specific application of indocyanine green in clinical dental practice.</description><identifier>ISSN: 0007-0610</identifier><identifier>EISSN: 1476-5373</identifier><identifier>DOI: 10.1038/sj.bdj.2013.790</identifier><identifier>PMID: 23969654</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/301/930 ; 692/700/565 ; Ablation ; Alveolar Bone Loss - drug therapy ; Alveolar Bone Loss - surgery ; Bone Substitutes - therapeutic use ; Combined Modality Therapy ; Dental Fistula - drug therapy ; Dental Fistula - surgery ; Dentistry ; Energy ; Energy Transfer ; Humans ; Indocyanine Green - therapeutic use ; Lasers ; Lasers, Semiconductor - therapeutic use ; Light ; Low-Level Light Therapy - instrumentation ; Low-Level Light Therapy - methods ; Medicine ; Oxidative stress ; Oxidative Stress - physiology ; Periodontal Diseases - drug therapy ; Periodontal Diseases - microbiology ; Periodontal Pocket - drug therapy ; Periodontal Pocket - microbiology ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents - therapeutic use ; practice ; Reactive Oxygen Species - therapeutic use ; Surgical Flaps - surgery ; Tissues ; Toxicity</subject><ispartof>British dental journal, 2013-08, Vol.215 (4), p.167-171</ispartof><rights>Springer Nature Limited 2013</rights><rights>Copyright Nature Publishing Group Aug 23, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-90496b5c5455be5f987faf26546b0fe43eefd9f46469a5d1b635e73ef3a4d8323</citedby><cites>FETCH-LOGICAL-c473t-90496b5c5455be5f987faf26546b0fe43eefd9f46469a5d1b635e73ef3a4d8323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.bdj.2013.790$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.bdj.2013.790$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23969654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parker, S.</creatorcontrib><title>The use of diffuse laser photonic energy and indocyanine green photosensitiser as an adjunct to periodontal therapy</title><title>British dental journal</title><addtitle>Br Dent J</addtitle><addtitle>Br Dent J</addtitle><description>Key Points
Explores anti-bacterial photodynamic therapy as an adjunct to other periodontal treatment therapies.
Outlines how indocyanine green photosensitiser may be activated using a diode laser wavelength (810 nm) to provide generalised bacteriocidal effect.
Describes how this treatment provides antibacterial action to augment scaling and root planing, as well as in open flap periodontal surgery.
Light-activated chemical therapy – generally known as photodynamic therapy (PDT) – has been developed within medicine, to allow the use of an applied agent (photosensitiser) that could be activated using laser photonic energy, leading to the destruction of target cellular structures. In clinical dentistry, PDT has been utilised within a wide scope of topical application in endodontic, periodontal and oral epithelial pathology where specifically, anti-bacterial action may prove useful. Underlying the complex and multi-factorial aetiology, periodontal disease remains of essentially-bacterial origin and anti-bacterial PDT (aPDT) has been investigated as an adjunctive to other periodontal treatment therapies. Of several topically-applied photosensitisers, one agent, indocyanine green, may be activated using a diode laser wavelength (810 nm) that is commonly-available in clinical dental practice, to provide generalised bacteriocidal effect. Unlike antibiotics and antibacterial mouthwashes, the mode of action appears to be nonspecific to bacterial species and is linked to cell death through a process of oxidative stress. Additionally, indocyanine green has otherwise low toxicity to non-target host tissue and dental restorative materials. This paper explores the background to this therapy, its position within the broader delivery of periodontal treatment and the specific application of indocyanine green in clinical dental practice.</description><subject>639/301/930</subject><subject>692/700/565</subject><subject>Ablation</subject><subject>Alveolar Bone Loss - drug therapy</subject><subject>Alveolar Bone Loss - surgery</subject><subject>Bone Substitutes - therapeutic use</subject><subject>Combined Modality Therapy</subject><subject>Dental Fistula - drug therapy</subject><subject>Dental Fistula - surgery</subject><subject>Dentistry</subject><subject>Energy</subject><subject>Energy Transfer</subject><subject>Humans</subject><subject>Indocyanine Green - therapeutic use</subject><subject>Lasers</subject><subject>Lasers, Semiconductor - therapeutic use</subject><subject>Light</subject><subject>Low-Level Light Therapy - instrumentation</subject><subject>Low-Level Light Therapy - methods</subject><subject>Medicine</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Periodontal Diseases - drug therapy</subject><subject>Periodontal Diseases - microbiology</subject><subject>Periodontal Pocket - drug therapy</subject><subject>Periodontal Pocket - microbiology</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>practice</subject><subject>Reactive Oxygen Species - therapeutic use</subject><subject>Surgical Flaps - surgery</subject><subject>Tissues</subject><subject>Toxicity</subject><issn>0007-0610</issn><issn>1476-5373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kD1v2zAQhokiRe26nbMFBDLLOYpf1lgYaVIgQBd3JijxaEuwSZWUBv_70rBbZOl0B9xz7x0eQu4ZrBnwzVMe1q0b1jUwvtYNfCBLJrSqJNf8jiwBQFegGCzI55wHACYEqE9kUfNGNUqKJcm7A9I5I42eut77S3u0GRMdD3GKoe8oBkz7M7XB0T642J1t6APSfUIMVypjyP3UX7ZsLiC1bphDN9Ep0hFTH10Mkz3S6YDJjucv5KO3x4xfb3VFfn1_3m1fq7efLz-2396qTmg-VQ2IRrWyk0LKFqVvNtpbX5e3VQseBUf0rvFCCdVY6ViruETN0XMr3IbXfEUer7ljir9nzJMZ4pxCOWmYqDUwXYMs1NOV6lLMOaE3Y-pPNp0NA3ORbPJgimRzkWyK5LLxcMud2xO6f_xfqwWAK5DLKOwxvTv8n8w_2HWK1A</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Parker, S.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20130801</creationdate><title>The use of diffuse laser photonic energy and indocyanine green photosensitiser as an adjunct to periodontal therapy</title><author>Parker, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-90496b5c5455be5f987faf26546b0fe43eefd9f46469a5d1b635e73ef3a4d8323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>639/301/930</topic><topic>692/700/565</topic><topic>Ablation</topic><topic>Alveolar Bone Loss - drug therapy</topic><topic>Alveolar Bone Loss - surgery</topic><topic>Bone Substitutes - therapeutic use</topic><topic>Combined Modality Therapy</topic><topic>Dental Fistula - drug therapy</topic><topic>Dental Fistula - surgery</topic><topic>Dentistry</topic><topic>Energy</topic><topic>Energy Transfer</topic><topic>Humans</topic><topic>Indocyanine Green - therapeutic use</topic><topic>Lasers</topic><topic>Lasers, Semiconductor - therapeutic use</topic><topic>Light</topic><topic>Low-Level Light Therapy - instrumentation</topic><topic>Low-Level Light Therapy - methods</topic><topic>Medicine</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Periodontal Diseases - drug therapy</topic><topic>Periodontal Diseases - microbiology</topic><topic>Periodontal Pocket - drug therapy</topic><topic>Periodontal Pocket - microbiology</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>practice</topic><topic>Reactive Oxygen Species - therapeutic use</topic><topic>Surgical Flaps - surgery</topic><topic>Tissues</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parker, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>British dental journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parker, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of diffuse laser photonic energy and indocyanine green photosensitiser as an adjunct to periodontal therapy</atitle><jtitle>British dental journal</jtitle><stitle>Br Dent J</stitle><addtitle>Br Dent J</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>215</volume><issue>4</issue><spage>167</spage><epage>171</epage><pages>167-171</pages><issn>0007-0610</issn><eissn>1476-5373</eissn><abstract>Key Points
Explores anti-bacterial photodynamic therapy as an adjunct to other periodontal treatment therapies.
Outlines how indocyanine green photosensitiser may be activated using a diode laser wavelength (810 nm) to provide generalised bacteriocidal effect.
Describes how this treatment provides antibacterial action to augment scaling and root planing, as well as in open flap periodontal surgery.
Light-activated chemical therapy – generally known as photodynamic therapy (PDT) – has been developed within medicine, to allow the use of an applied agent (photosensitiser) that could be activated using laser photonic energy, leading to the destruction of target cellular structures. In clinical dentistry, PDT has been utilised within a wide scope of topical application in endodontic, periodontal and oral epithelial pathology where specifically, anti-bacterial action may prove useful. Underlying the complex and multi-factorial aetiology, periodontal disease remains of essentially-bacterial origin and anti-bacterial PDT (aPDT) has been investigated as an adjunctive to other periodontal treatment therapies. Of several topically-applied photosensitisers, one agent, indocyanine green, may be activated using a diode laser wavelength (810 nm) that is commonly-available in clinical dental practice, to provide generalised bacteriocidal effect. Unlike antibiotics and antibacterial mouthwashes, the mode of action appears to be nonspecific to bacterial species and is linked to cell death through a process of oxidative stress. Additionally, indocyanine green has otherwise low toxicity to non-target host tissue and dental restorative materials. This paper explores the background to this therapy, its position within the broader delivery of periodontal treatment and the specific application of indocyanine green in clinical dental practice.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23969654</pmid><doi>10.1038/sj.bdj.2013.790</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 639/301/930 692/700/565 Ablation Alveolar Bone Loss - drug therapy Alveolar Bone Loss - surgery Bone Substitutes - therapeutic use Combined Modality Therapy Dental Fistula - drug therapy Dental Fistula - surgery Dentistry Energy Energy Transfer Humans Indocyanine Green - therapeutic use Lasers Lasers, Semiconductor - therapeutic use Light Low-Level Light Therapy - instrumentation Low-Level Light Therapy - methods Medicine Oxidative stress Oxidative Stress - physiology Periodontal Diseases - drug therapy Periodontal Diseases - microbiology Periodontal Pocket - drug therapy Periodontal Pocket - microbiology Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - therapeutic use practice Reactive Oxygen Species - therapeutic use Surgical Flaps - surgery Tissues Toxicity |
title | The use of diffuse laser photonic energy and indocyanine green photosensitiser as an adjunct to periodontal therapy |
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