The association between the PPAR[gamma]2 Pro12Ala polymorphism and nephropathy susceptibility in type 2 diabetes: a meta-analysis based on 9,176 subjects

Background The polymorphism Pro12Ala in peroxisome proliferator-activated receptor­[gamma]2 gene (PPAR[gamma]2) has been reported to be associated with diabetic nephropathy (DN) in some studies, though the results remain inconclusive. To explore this relationship between PPAR[gamma]2 Pro12Ala polym...

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Veröffentlicht in:Diagnostic pathology 2013-07, Vol.8
Hauptverfasser: Wang, Lei, Teng, Zan, Cai, Shuang, Wang, Difei, Zhao, Xin, Yu, Kai
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Sprache:eng
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Zusammenfassung:Background The polymorphism Pro12Ala in peroxisome proliferator-activated receptor­[gamma]2 gene (PPAR[gamma]2) has been reported to be associated with diabetic nephropathy (DN) in some studies, though the results remain inconclusive. To explore this relationship between PPAR[gamma]2 Pro12Ala polymorphism and the susceptibility for DN, a cumulative meta-analysis was performed in this study. Method PubMed, Medline, Embase and Web of Science databases have been systematically searched to identify relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results 18 studies were included in this meta-analysis, involving 3,361 cases and 5,815 controls. The PPAR[gamma]2 Ala12 allele was significantly associated with decreased risk of DN based on dominant model (OR=0.778; 95%CI=0.618-0.981; P.sub.heterogeneity=0.008; P=0.034). In the stratified analysis by ethnicity, significantly decreased risks were found among Caucasians for dominant model (OR=0.674; 95%CI=0.500-0.909; P.sub.heterogeneity=0.079; P=0.010), while there was no significant association was found in Asians. Conclusions The results from the present meta-analysis indicated that the Pro12Ala polymorphism in PPAR[gamma]2 gene is not a risk factor for DN in type 2 diabetes (T2D). Further large and well-designed studies are needed to confirm this conclusion. Virtual slides The virtual slides for this article can be found here: Keywords: PPAR[gamma]2, Meta-analysis, Diabetic nephropathy, Polymorphisms
ISSN:1746-1596
1746-1596
DOI:10.1186/1746-1596-8-118