Structure of Gefitinib
The crystal of the title compound, C22H24ClFN4O3, belongs to space group P1 with cell dimensions of a = 8.928(1), b = 9.717(2), c = 12.604(2)Å, α = 93.31(1), and β = 97.12(1), and γ = 101.47(1)°. The final R value is 0.053. The quinazoline and benzene rings are nearly coplanar. The conformation is m...
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| Veröffentlicht in: | Analytical Sciences ; X-ray Structure and Analysis Online 2004, Vol.20, pp.x173-x174 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The crystal of the title compound, C22H24ClFN4O3, belongs to space group P1 with cell dimensions of a = 8.928(1), b = 9.717(2), c = 12.604(2)Å, α = 93.31(1), and β = 97.12(1), and γ = 101.47(1)°. The final R value is 0.053. The quinazoline and benzene rings are nearly coplanar. The conformation is maintained by an intramolecular C-H…N hydrogen bond. The morpholine ring is almost perpendicular to the quinazoline ring. |
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| ISSN: | 1348-2238 1348-2238 1883-3578 |
| DOI: | 10.2116/analscix.20.x173 |