ChemInform Abstract: A One-Pot, Multi-Component Reaction for the Synthesis of Fully Substituted 5-Amino-4-carboxamide-thiazoles

ChemInform Abstract: A One-Pot, Multi-Component Reaction for the Synthesis of Fully Substituted 5-Amino-4-carboxamide-thiazoles

Various target compounds, intermediates in the preparation of pharmacologically active substances, are directly obtained by base‐promoted condensation of 2‐amido‐2‐cyanoacetamide (I) with a variety of aldehydes in the presence of elemental sulfur.

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Bibliographische Detailangaben
Veröffentlicht in:ChemInform 2013-08, Vol.44 (34), p.no-no
Hauptverfasser: Childers, Kaleen K., Haidle, Andrew M., Machacek, Michelle R., Rogers, J. Patrick, Romeo, Eric
Format: Artikel
Sprache:eng
Schlagworte:
multicomponent reactions
thiadiazole derivatives
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Beschreibung
Zusammenfassung:Various target compounds, intermediates in the preparation of pharmacologically active substances, are directly obtained by base‐promoted condensation of 2‐amido‐2‐cyanoacetamide (I) with a variety of aldehydes in the presence of elemental sulfur.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201334136