Auditory Hallucinations Associated With Paget’s Disease

There have been previous accounts in the literature, which reported findings of memory impairment, depressive, and psychotic symptoms in the form of delusions,5-7 but none of these cases have reported the existence of auditory hallucinations. [...]it is worth mentioning that there is a syndrome of inclusion-body myopathy associated with Paget's disease of the bone (PDB) and/or frontotemporal dementia (IBMPFD), characterized by early-onset PDB, premature frontotemporal dementia (FTD), and adult-onset proximal and distal muscle weakness clinically resembling a limb-girdle muscular dystrophy syndrome. A possible hypothesis proposes that the enlarging, deformed Pagetic bone can cause pressure on the brain, spinal cord, or nerves, thereby reducing blood flow to these areas of the brain and spinal cord, and also by affecting the physical conformation of the skull and vertebral column.7 Manifestation of neuropsychiatric symptoms in Paget's disease remains rare.7,8 Wyllie has maintained that the nervous system is rarely affected because the spatial capacity of the cranium actually increases with disease progression.