Clozapine-Induced Restless Legs Syndrome Treated With Aripiprazole

Case Report "Ms. M," a 34-year-old woman with a 12-year history of treatment-resistant paranoid schizophrenia, having auditory hallucinations and multiple delusions, had poor response to adequate trials of haloperidol, risperidone, and injection fluphenazine. Because of treatment nonresponse, she was started on clozapine, which was increased to 200 mg. Aripiprazole also had the added benefit of having a synergistic effect with clozapine,11 which enabled in improvement in the psychotic symptoms and enabled further increase in clozapine dosage, as well. [...]in antipsychotic-induced RLS, aripiprazole could be considered, as it would also have an added antipsychotic effect and, in a case like this, wherein the antipsychotic could not be stopped, as the patient was a nonresponder, and the psychotic symptoms were very severe.