Combined toxicity of penicillin and aspirin therapy may elicit bilateral vestibulopathy
[...]aspirin has been found to modulate cochlear neurotoxicity of gentamicin, but an interaction between aspirin and penicillin has not been examined yet. [...]ampicillin and NSAIDs have been shown to compete for protein binding. [...]penicillin may elevate the free serum concentrations of NSAIDs an...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 2013-07, Vol.115 (7), p.1114-1116 |
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| container_title | Clinical neurology and neurosurgery |
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| creator | Hertel, S Schwaninger, M Helmchen, C |
| description | [...]aspirin has been found to modulate cochlear neurotoxicity of gentamicin, but an interaction between aspirin and penicillin has not been examined yet. [...]ampicillin and NSAIDs have been shown to compete for protein binding. [...]penicillin may elevate the free serum concentrations of NSAIDs and enhance their toxicity. |
| doi_str_mv | 10.1016/j.clineuro.2012.08.033 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0303-8467 |
| ispartof | Clinical neurology and neurosurgery, 2013-07, Vol.115 (7), p.1114-1116 |
| issn | 0303-8467 1872-6968 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Aged Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Aspirin Aspirin - adverse effects Aspirin - therapeutic use Ataxia Bilateral vestibulopathy Drug dosages Electronystagmography Female Gait Disorders, Neurologic - etiology Humans Irrigation Male Medical treatment Neurologic Examination Neurology Neurosurgery NSAIDs Patients Penicillin Penicillins - adverse effects Penicillins - therapeutic use Pyridines - adverse effects Pyridines - therapeutic use Reflex, Vestibulo-Ocular - physiology Street signs Studies Sulfones - adverse effects Sulfones - therapeutic use Toxicity Tumors Vertigo Vestibular Diseases - chemically induced Vestibular Diseases - physiopathology Vestibular Evoked Myogenic Potentials - physiology Vestibular Function Tests |
| title | Combined toxicity of penicillin and aspirin therapy may elicit bilateral vestibulopathy |
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