Combined toxicity of penicillin and aspirin therapy may elicit bilateral vestibulopathy

[...]aspirin has been found to modulate cochlear neurotoxicity of gentamicin, but an interaction between aspirin and penicillin has not been examined yet. [...]ampicillin and NSAIDs have been shown to compete for protein binding. [...]penicillin may elevate the free serum concentrations of NSAIDs an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical neurology and neurosurgery 2013-07, Vol.115 (7), p.1114-1116
Hauptverfasser:	Hertel, S, Schwaninger, M, Helmchen, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Aspirin Aspirin - adverse effects Aspirin - therapeutic use Ataxia Bilateral vestibulopathy Drug dosages Electronystagmography Female Gait Disorders, Neurologic - etiology Humans Irrigation Male Medical treatment Neurologic Examination Neurology Neurosurgery NSAIDs Patients Penicillin Penicillins - adverse effects Penicillins - therapeutic use Pyridines - adverse effects Pyridines - therapeutic use Reflex, Vestibulo-Ocular - physiology Street signs Studies Sulfones - adverse effects Sulfones - therapeutic use Toxicity Tumors Vertigo Vestibular Diseases - chemically induced Vestibular Diseases - physiopathology Vestibular Evoked Myogenic Potentials - physiology Vestibular Function Tests
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	[...]aspirin has been found to modulate cochlear neurotoxicity of gentamicin, but an interaction between aspirin and penicillin has not been examined yet. [...]ampicillin and NSAIDs have been shown to compete for protein binding. [...]penicillin may elevate the free serum concentrations of NSAIDs and enhance their toxicity.
ISSN:	0303-8467 1872-6968
DOI:	10.1016/j.clineuro.2012.08.033