Endogenous Antibody Interferences in Immunoassays

The potential for interfering substances to cause inaccurate laboratory results that may cause significant adverse effects on patient care is well known. Immunoassays are subject to interferences that are not readily detectable prior to analysis, but may cause erroneous results. After reading this article, readers should understand potential causes of interference that are specific to immunoassays, methods used to detect interference, and approaches used to resolve discrepancies between laboratory results and the clinical picture.