Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E [epsilon]4, and the Risk of Late-Onset Alzheimer Disease in African Americans

Reitz et al identify genetic loci associated with late-onset Alzheimer disease in African Americans. In this meta-analysis of data from African American participants, Alzheimer disease was significantly associated with variants in ABCA7 and with other genes that have been associated with Alzheimer d...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2013-04, Vol.309 (14), p.1483
Hauptverfasser:	Reitz, Christiane, Jun, Gyungah, Naj, Adam, Rajbhandary, Ruchita, Vardarajan, Badri Narayan, Wang, Li-San, Valladares, Otto, Lin, Chiao-Feng, Larson, Eric B, Graff-Radford, Neill R, Evans, Denis, De Jager, Philip L, Crane, Paul K, Buxbaum, Joseph D, Murrell, Jill R, Raj, Towfique, Ertekin-Taner, Nilufer, Logue, Mark, Baldwin, Clinton T, Green, Robert C, Barnes, Lisa L, Cantwell, Laura B, Fallin, M Daniele, Go, Rodney C P, Griffith, Patrick, Obisesan, Thomas O, Manly, Jennifer J, Lunetta, Kathryn L, Kamboh, M Ilyas, Lopez, Oscar L, Bennett, David A, Hendrie, Hugh
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Alzheimer's disease Gene loci Genes Meta-analysis Systematic review
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Zusammenfassung:	Reitz et al identify genetic loci associated with late-onset Alzheimer disease in African Americans. In this meta-analysis of data from African American participants, Alzheimer disease was significantly associated with variants in ABCA7 and with other genes that have been associated with Alzheimer disease in individuals of European ancestry. Replication and functional validation of this finding is needed before this information is used in clinical settings.
ISSN:	0098-7484 1538-3598