K. pneumoniae and beta-lactamases. A rising issue

The increase in bacterial resistance is a rising phenomenon around the world, Klebsiella pneumoniae is one of the most important pathogens causing nosocomial infection being also associated to high resistance to betalactam antibiotics, mostly due to the presence of enzymes known as betalactameses. ßlactam antibiotics are the most prescribed antibiotics throughout the world, its use corresponding to approximately 50% of global use. The following review highlights the importance of the study and detection of Blactamases in K. penaumoniae strains. The following paper describes the importance of K. pneumoniae as a nosocomial pathogen in the country and in the city and compares the situation to other areas of the world. A description of Blactamases, their classification and target substrates is provided. In addition, the methods for detection of these enzymes by the clinical laboratory is also provided.