Biodegradable ZnO@polymer Core-Shell Nanocarriers: pH-Triggered Release of Doxorubicin InVitro
Luminescent ZnO@polymer core-shell nanoparticles were synthesized and loaded with doxorubicin (DOX) for the treatment of human brain cancer cells. Analyses by confocal laser scanning microscopy proved that the ZnO@polymer-DOX nanocomposites were decomposed at lysosomes to release DOX molecules, whic...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2013-04, Vol.52 (15), p.4127 |
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| container_issue | 15 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 52 |
| creator | Zhang, Zheng-Yong Xu, Yu-Dong Ma, Ying-Ying Qiu, Li-Li Wang, Yi Kong, Ji-Lie Xiong, Huan-Ming |
| description | Luminescent ZnO@polymer core-shell nanoparticles were synthesized and loaded with doxorubicin (DOX) for the treatment of human brain cancer cells. Analyses by confocal laser scanning microscopy proved that the ZnO@polymer-DOX nanocomposites were decomposed at lysosomes to release DOX molecules, which penetrated into the nucleus and finally killed the cells. |
| doi_str_mv | 10.1002/anie.201300431 |
| format | Article |
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| title | Biodegradable ZnO@polymer Core-Shell Nanocarriers: pH-Triggered Release of Doxorubicin InVitro |
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