Biodegradable ZnO@polymer Core-Shell Nanocarriers: pH-Triggered Release of Doxorubicin InVitro

Biodegradable ZnO@polymer Core-Shell Nanocarriers: pH-Triggered Release of Doxorubicin InVitro

Luminescent ZnO@polymer core-shell nanoparticles were synthesized and loaded with doxorubicin (DOX) for the treatment of human brain cancer cells. Analyses by confocal laser scanning microscopy proved that the ZnO@polymer-DOX nanocomposites were decomposed at lysosomes to release DOX molecules, whic...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-04, Vol.52 (15), p.4127
Hauptverfasser: Zhang, Zheng-Yong, Xu, Yu-Dong, Ma, Ying-Ying, Qiu, Li-Li, Wang, Yi, Kong, Ji-Lie, Xiong, Huan-Ming
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Sprache:eng
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Zusammenfassung:Luminescent ZnO@polymer core-shell nanoparticles were synthesized and loaded with doxorubicin (DOX) for the treatment of human brain cancer cells. Analyses by confocal laser scanning microscopy proved that the ZnO@polymer-DOX nanocomposites were decomposed at lysosomes to release DOX molecules, which penetrated into the nucleus and finally killed the cells.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201300431