Reactions of N3-Substituted Amidrazones with cis-1,2-Cyclohexanedicarboxylic Anhydride and Biological Activities of the Products
A series of novel compounds were synthesized in reactions of N3‐substituted amidrazones with cis‐1,2‐cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures were confirmed by H1 NMR and IR spectrometry as well as elemental analysis. Potential biological eff...
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| Veröffentlicht in: | Archiv der Pharmazie (Weinheim) 2012-06, Vol.345 (6), p.486-494 |
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| container_title | Archiv der Pharmazie (Weinheim) |
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| creator | Modzelewska-Banachiewicz, Bozena Ucherek, Marzena Zimecki, Michał Kutkowska, Jolanta Kaminska, Teresa Morak-Młodawska, Beata Paprocka, Renata Szulc, Michał Lewandowski, Grzegorz Marciniak, Joanna Bobkiewicz-Kozlowska, Teresa |
| description | A series of novel compounds were synthesized in reactions of N3‐substituted amidrazones with cis‐1,2‐cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures were confirmed by H1 NMR and IR spectrometry as well as elemental analysis. Potential biological effects of new compounds were predicted with the Prediction of Activity Spectra for Substances (PASS) program. Antiviral, antibacterial, analgesic, and anti‐inflammatory activities were experimentally verified.
A series of novel compounds were synthesized in reactions of N3‐substituted amidrazones with cis‐1,2‐cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. The potential biological effects of the new compounds were predicted with the PASS program. Antiviral, antibacterial, analgesic, and anti‐inflammatory activities were verified experimentally. |
| doi_str_mv | 10.1002/ardp.201100333 |
| format | Article |
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A series of novel compounds were synthesized in reactions of N3‐substituted amidrazones with cis‐1,2‐cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. The potential biological effects of the new compounds were predicted with the PASS program. Antiviral, antibacterial, analgesic, and anti‐inflammatory activities were verified experimentally.</description><subject>Analgesic activity</subject><subject>Anti-bacterial activity</subject><subject>Anti-inflammatory activity</subject><subject>Synthesis</subject><issn>0365-6233</issn><issn>1521-4184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNo9kM1v1DAQxS0EEsvClbMlrrj1V-LkmC5QQG0pBURvlmNPWJc0Xmyn3XDqn960W-1p9DTvzdP8EHrL6AGjlB-a6DYHnLJZCCGeoQUrOCOSVfI5WlBRFqTkQrxEr1K6orOH8mKB7i7A2OzDkHDo8JkgP8Y2ZZ_HDA43195F8z8MkPCtz2tsfSLsPSeryfZhDVszgPPWxDZsp95b3AzryUXvAJvB4SMf-vBn3ve4mTtufPbwWJPXgM9jcKPN6TV60Zk-wZunuUS_Pn38ufpMTr4df1k1J8TPLwlirWnrupC2LouCy65snYRWma6islNAwQlZccU7R12pZCeVg7aDVlaFUBVvxRK9293dxPBvhJT1VRjjMFdqJjjndclnPEtU71y3vodJb6K_NnHSjOoHxPoBsd4j1s3Fh_O9mrNkl_Upw3afNfGvLpVQhf59dqyPLi9Pv35XpT4V97mOg00</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Modzelewska-Banachiewicz, Bozena</creator><creator>Ucherek, Marzena</creator><creator>Zimecki, Michał</creator><creator>Kutkowska, Jolanta</creator><creator>Kaminska, Teresa</creator><creator>Morak-Młodawska, Beata</creator><creator>Paprocka, Renata</creator><creator>Szulc, Michał</creator><creator>Lewandowski, Grzegorz</creator><creator>Marciniak, Joanna</creator><creator>Bobkiewicz-Kozlowska, Teresa</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>K9.</scope></search><sort><creationdate>201206</creationdate><title>Reactions of N3-Substituted Amidrazones with cis-1,2-Cyclohexanedicarboxylic Anhydride and Biological Activities of the Products</title><author>Modzelewska-Banachiewicz, Bozena ; Ucherek, Marzena ; Zimecki, Michał ; Kutkowska, Jolanta ; Kaminska, Teresa ; Morak-Młodawska, Beata ; Paprocka, Renata ; Szulc, Michał ; Lewandowski, Grzegorz ; Marciniak, Joanna ; Bobkiewicz-Kozlowska, Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2013-ccab9954c965524f6bd4eb7af804f7e0ed348272fd0d674f47debfeb4853782b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analgesic activity</topic><topic>Anti-bacterial activity</topic><topic>Anti-inflammatory activity</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Modzelewska-Banachiewicz, Bozena</creatorcontrib><creatorcontrib>Ucherek, Marzena</creatorcontrib><creatorcontrib>Zimecki, Michał</creatorcontrib><creatorcontrib>Kutkowska, Jolanta</creatorcontrib><creatorcontrib>Kaminska, Teresa</creatorcontrib><creatorcontrib>Morak-Młodawska, Beata</creatorcontrib><creatorcontrib>Paprocka, Renata</creatorcontrib><creatorcontrib>Szulc, Michał</creatorcontrib><creatorcontrib>Lewandowski, Grzegorz</creatorcontrib><creatorcontrib>Marciniak, Joanna</creatorcontrib><creatorcontrib>Bobkiewicz-Kozlowska, Teresa</creatorcontrib><collection>Istex</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Archiv der Pharmazie (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Modzelewska-Banachiewicz, Bozena</au><au>Ucherek, Marzena</au><au>Zimecki, Michał</au><au>Kutkowska, Jolanta</au><au>Kaminska, Teresa</au><au>Morak-Młodawska, Beata</au><au>Paprocka, Renata</au><au>Szulc, Michał</au><au>Lewandowski, Grzegorz</au><au>Marciniak, Joanna</au><au>Bobkiewicz-Kozlowska, Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reactions of N3-Substituted Amidrazones with cis-1,2-Cyclohexanedicarboxylic Anhydride and Biological Activities of the Products</atitle><jtitle>Archiv der Pharmazie (Weinheim)</jtitle><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><date>2012-06</date><risdate>2012</risdate><volume>345</volume><issue>6</issue><spage>486</spage><epage>494</epage><pages>486-494</pages><issn>0365-6233</issn><eissn>1521-4184</eissn><abstract>A series of novel compounds were synthesized in reactions of N3‐substituted amidrazones with cis‐1,2‐cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures were confirmed by H1 NMR and IR spectrometry as well as elemental analysis. Potential biological effects of new compounds were predicted with the Prediction of Activity Spectra for Substances (PASS) program. Antiviral, antibacterial, analgesic, and anti‐inflammatory activities were experimentally verified.
A series of novel compounds were synthesized in reactions of N3‐substituted amidrazones with cis‐1,2‐cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. The potential biological effects of the new compounds were predicted with the PASS program. Antiviral, antibacterial, analgesic, and anti‐inflammatory activities were verified experimentally.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/ardp.201100333</doi><tpages>9</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Analgesic activity Anti-bacterial activity Anti-inflammatory activity Synthesis |
| title | Reactions of N3-Substituted Amidrazones with cis-1,2-Cyclohexanedicarboxylic Anhydride and Biological Activities of the Products |
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