Reactions of N3-Substituted Amidrazones with cis-1,2-Cyclohexanedicarboxylic Anhydride and Biological Activities of the Products

A series of novel compounds were synthesized in reactions of N3‐substituted amidrazones with cis‐1,2‐cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures were confirmed by H1 NMR and IR spectrometry as well as elemental analysis. Potential biological effects of new compounds were predicted with the Prediction of Activity Spectra for Substances (PASS) program. Antiviral, antibacterial, analgesic, and anti‐inflammatory activities were experimentally verified. A series of novel compounds were synthesized in reactions of N3‐substituted amidrazones with cis‐1,2‐cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. The potential biological effects of the new compounds were predicted with the PASS program. Antiviral, antibacterial, analgesic, and anti‐inflammatory activities were verified experimentally.