Pretransplant Interferon-[gamma] Secretion by CMV-Specific CD8+ T Cells Informs the Risk of CMV Replication After Transplantation

Pretransplant Interferon-[gamma] Secretion by CMV-Specific CD8+ T Cells Informs the Risk of CMV Replication After Transplantation

In this prospective study we analyzed pretransplant interferon-[gamma] secretion by cytomegalovirus (CMV)-specific CD8+ T cells to assess its possible utility in determining the risk of CMV replication after solid organ transplantation. A total of 113 lung and kidney transplant patients were enrolle...

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Veröffentlicht in:American journal of transplantation 2013-03, Vol.13 (3), p.738
Hauptverfasser: Cantisán, S, Lara, R, Montejo, M, Redel, J, Rodríguez-Benot, A, Gutiérrez-Aroca, J, González-Padilla, M, Bueno, L, Rivero, A, Solana, R, Torre-Cisneros, J
Format: Artikel
Sprache:eng
Schlagworte:
Blood & organ donations
Cytomegalovirus
Lymphocytes
Transplants & implants
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Zusammenfassung:In this prospective study we analyzed pretransplant interferon-[gamma] secretion by cytomegalovirus (CMV)-specific CD8+ T cells to assess its possible utility in determining the risk of CMV replication after solid organ transplantation. A total of 113 lung and kidney transplant patients were enrolled in the study but only 55 were evaluable. All CMV-seronegative recipients were pretransplant "nonreactive" (IFN[gamma]
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.12049