Effective and Versatile Strategy for the Total Solid-Phase Synthesis of Alkanethiols for Biological Applications

Biological applications increasingly demand tailored surfaces with a range of functional groups. Herein we describe a straightforward and inexpensive method based exclusively on solid‐phase synthesis for the preparation of a variety of customized alkanethiols (ATs). The technique overcomes all the difficulties encountered during the preparation of these molecules in solution. The procedure allows the use of ATs without further purification for the preparation of self‐assembled monolayers on gold, typically used to achieve functional group diversity on this surface. This paper describes a straightforward and inexpensive method based exclusively on solid‐phase synthesis for the preparation of a variety of customized alkanethiols (ATs). The technique allows a variety of ATs to be obtained in only three steps, overcoming the difficulties encountered during their preparation in solution.