ChemInform Abstract: Combined [alpha],[alpha]-Dialkylprolinol Ether/Broensted Acid Promotes Mannich Reactions of Aldehydes with Unactivated Imines. An Entry to anti-Configured Propargylic Amino Alcohols

ChemInform Abstract: Combined [alpha],[alpha]-Dialkylprolinol Ether/Broensted Acid Promotes Mannich Reactions of Aldehydes with Unactivated Imines. An Entry to anti-Configured Propargylic Amino Alcohols

A series of amino alcohols (III) and (IX) is prepared with 80--98% diastereomeric excess using a hitherto not reported enamine-mediated antiselective Mannich reaction of corresponding imines with aldehydes (II). [PUBLICATION ABSTRACT]

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Veröffentlicht in:ChemInform 2013-03, Vol.44 (12), p.no
Hauptverfasser: Gomez-Bengoa, Enrique, Jimenez, Jacqueline, Lapuerta, Irati, Mielgo, Antonia, Oiarbide, Mikel, Otazo, Itziar, Velilla, Irene, Vera, Silvia, Palomo, Claudio
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
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Zusammenfassung:A series of amino alcohols (III) and (IX) is prepared with 80--98% diastereomeric excess using a hitherto not reported enamine-mediated antiselective Mannich reaction of corresponding imines with aldehydes (II). [PUBLICATION ABSTRACT]
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201312058