Improved detection of toxigenic Clostridium difficile using the Cepheid Xpert C difficile assay and impact on C difficile infection rates in a tertiary hospital: A double-edged sword

Recent recommendations suggest implementation of a 2-step diagnostic algorithm for the laboratory detection of toxigenic Clostridium difficile . We found that the rate of toxigenic C difficile detection in our laboratory doubled after the introduction of an algorithm that incorporated polymerase cha...

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Veröffentlicht in:	American journal of infection control 2013-03, Vol.41 (3), p.270-272
Hauptverfasser:	Williamson, Deborah A., MD, Basu, Indira, PhD, Freeman, Joshua, MD, Swager, Terri, MLS, Roberts, Sally A., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacterial infections Bacterial Toxins - biosynthesis Bacterial Toxins - genetics Bacteriological Techniques - methods Biological and medical sciences Clostridium difficile Clostridium difficile - isolation & purification Clostridium difficile - pathogenicity Clostridium Infections - diagnosis Clostridium Infections - epidemiology Clostridium Infections - microbiology Diagnosis Epidemiology. Vaccinations Gastroenterology. Liver. Pancreas. Abdomen General aspects Gram-positive bacteria Human bacterial diseases Humans Infection Infection Control Infectious Disease Infectious diseases Medical diagnosis Medical sciences Other diseases. Semiology Polymerase chain reaction Polymerase Chain Reaction - methods Prevalence Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tertiary Care Centers
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Beschreibung
Zusammenfassung:	Recent recommendations suggest implementation of a 2-step diagnostic algorithm for the laboratory detection of toxigenic Clostridium difficile . We found that the rate of toxigenic C difficile detection in our laboratory doubled after the introduction of an algorithm that incorporated polymerase chain reaction testing. This led to an abrupt 70% increase in the overall rate of C difficile infection in our institution.
ISSN:	0196-6553 1527-3296
DOI:	10.1016/j.ajic.2012.03.025