Inside Cover: The C-Terminal Extended Serine Residue Is Absolutely Required in Nosiheptide Maturation (ChemBioChem 5/2013)

Inside Cover: The C-Terminal Extended Serine Residue Is Absolutely Required in Nosiheptide Maturation (ChemBioChem 5/2013)

Serine qua non: Substitution of the extended Ser13 in the core peptide of nosiheptide by analogous amino acids prevented enamide dealkylation of the terminal residue for nosiheptide maturation.

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Bibliographische Detailangaben
Veröffentlicht in:Chembiochem : a European journal of chemical biology 2013-03, Vol.14 (5), p.526-526
Hauptverfasser: Liu, Weiying, Ma, Min, Xue, Yanjiu, Liu, Nan, Wang, Shuzhen, Chen, Yijun
Format: Artikel
Sprache:eng
Schlagworte:
biosynthesis
enamide dealkylation
nosiheptide
post-translational modifications
thiopeptides
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Beschreibung
Zusammenfassung:Serine qua non: Substitution of the extended Ser13 in the core peptide of nosiheptide by analogous amino acids prevented enamide dealkylation of the terminal residue for nosiheptide maturation.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201390013