The helix turns at 60: writhing free in chromosomes

Dynamic supercoiling is a steady-state mechanical regulatory mechanism that influences DNA topology, transcription factor binding, gene expression, chromatin structure and long-range chromosome interactions. How genes and nongene regions are organized into supercoiled domains and remodeled by transc...

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Veröffentlicht in:	Nature structural & molecular biology 2013-03, Vol.20 (3), p.251-253
1. Verfasser:	Sinden, Richard R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/212/177 631/337/103 631/45/535 Biochemistry Biological Microscopy Chromatin - chemistry Chromatin Assembly and Disassembly Chromosomes Deoxyribonucleic acid DNA DNA, Superhelical - chemistry Gene expression Gene Expression Regulation Genetic transcription Genome, Human Humans Life Sciences Membrane Biology Molecular biology news-and-views Physiological aspects Protein Structure Structure Topology Transcription, Genetic
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Beschreibung
Zusammenfassung:	Dynamic supercoiling is a steady-state mechanical regulatory mechanism that influences DNA topology, transcription factor binding, gene expression, chromatin structure and long-range chromosome interactions. How genes and nongene regions are organized into supercoiled domains and remodeled by transcriptional activity in human cells has now been analyzed in two large-scale studies at the chromosome and genome levels, providing new insight into the organization and expression of genes within chromosomes.
ISSN:	1545-9993 1545-9985
DOI:	10.1038/nsmb.2533