Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes: e1001311

Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes: e1001311

Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. Recent studies have greatly expanded the number of established SLE risk alleles, but the distribution of multiple risk alleles in cases versus controls and their relationship to subphenoty...

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Veröffentlicht in:PLoS genetics 2011-02, Vol.7 (2)
Hauptverfasser: Taylor, Kimberly E, Chung, Sharon A, Graham, Robert R, Ortmann, Ward A, Lee, Annette T, Langefeld, Carl D, Jacob, Chaim O, Kamboh, M Ilyas, Alarcón-Riquelme, Marta E, Tsao, Betty P, Moser, Kathy L, Gaffney, Patrick M, Harley, John B, Petri, Michelle, Manzi, Susan, Gregersen, Peter K, Behrens, Timothy W, Criswell, Lindsey A
Format: Artikel
Sprache:eng
Schlagworte:
Autoimmune diseases
Kidney diseases
Lupus
Studies
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Zusammenfassung:Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. Recent studies have greatly expanded the number of established SLE risk alleles, but the distribution of multiple risk alleles in cases versus controls and their relationship to subphenotypes have not been studied. We studied 22 SLE susceptibility polymorphisms with previous genome-wide evidence of association (p
ISSN:1553-7390
1553-7404
DOI:10.1371/journal.pgen.1001311