THE IMPORTANCE OF INTRAVENOUS IMMUNOGLOBULINS IN THETREATMENT OF ADULT HEMATOLOGICAL DISEASES

BACKGROUND Intravenous immunoglobulins (IVIG) are preparations made from human plasma andcontain beside immunoglobulin G a wide spectrum of other endemic antibodies againstinfectious diseases typical for Slovenia. The purpose of treatment with IVIG is to restorenormal immunoregulatory mechanisms in human body. The use of IVIG is different: asreplacement therapy in primary and secondary immunodefficiency (lack of antibodies,impossibility of producing antibodies), as prophylactic treatment of some infections (cytomegalovirus, parvovirus B19) and for treatment of autoimmune diseases as idiopathicthrombocytopenic purpura. CONCLUSIONS As showed with pharmacokinetics study in patients with chronic lymphocytic leukemiaand multiple myeloma, IVIG has no influence on normal distribution of IgG and otherantibodies. In the paper there are shown multiple possible mechanisms of IVIG action,although they haven't been understood yet. There is a big possibility that some otherantibodies, which are present in the IVIG, are involved. The relative good effect of IVIGtreatment in different hematological diseases became of interest for prevention and treatment of some neurologic and neuromuscular diseases