Pharmacokinetic interaction of disulfiram and antidepressants

Pharmacokinetic interaction of disulfiram and antidepressants

Intravenous imipramine and desipramine were administered to two detoxified alcoholics before and during disulfiram treatment. Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak...

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Veröffentlicht in:The American journal of psychiatry 1985-11, Vol.142 (11), p.1373-1374
Hauptverfasser: CIRAULO, D. A, BARNHILL, J, BOXENBAUM, H
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Alcoholism - metabolism
Alcoholism - prevention & control
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Desipramine - metabolism
Desipramine - pharmacology
Disulfiram - pharmacology
Drug Interactions
Half-Life
Humans
Hydroxylation
Imipramine - metabolism
Imipramine - pharmacology
Kinetics
Male
Medical sciences
Middle Aged
Toxicology
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Beschreibung
Zusammenfassung:Intravenous imipramine and desipramine were administered to two detoxified alcoholics before and during disulfiram treatment. Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak plasma levels during disulfiram treatment.
ISSN:0002-953X
1535-7228
DOI:10.1176/ajp.142.11.1373