Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients
Among 18 elderly depressed patients given ECGs before and during nortriptyline treatment, plasma E-10-hydroxynortriptyline and the sum of E-10-hydroxynortriptyline and nortriptyline distinguished the group with conduction/repolarization effects. Plasma nortriptyline, age, drug dose, and baseline car...
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Veröffentlicht in: | The American journal of psychiatry 1985-07, Vol.142 (7), p.866-868 |
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container_title | The American journal of psychiatry |
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creator | YOUNG, R. C ALEXOPOULOS, G. S SHAMOIAN, C. A KENT, E DHAR, A. K KUTT, H |
description | Among 18 elderly depressed patients given ECGs before and during
nortriptyline treatment, plasma E-10-hydroxynortriptyline and the sum of
E-10-hydroxynortriptyline and nortriptyline distinguished the group with
conduction/repolarization effects. Plasma nortriptyline, age, drug dose,
and baseline cardiovascular status did not. |
doi_str_mv | 10.1176/ajp.142.7.866 |
format | Article |
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nortriptyline treatment, plasma E-10-hydroxynortriptyline and the sum of
E-10-hydroxynortriptyline and nortriptyline distinguished the group with
conduction/repolarization effects. Plasma nortriptyline, age, drug dose,
and baseline cardiovascular status did not.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.142.7.866</identifier><identifier>PMID: 4014510</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Age Factors ; Aged ; Arrhythmias, Cardiac - chemically induced ; Arrhythmias, Cardiac - diagnosis ; Biological and medical sciences ; Depressive Disorder - blood ; Depressive Disorder - drug therapy ; Depressive Disorder - physiopathology ; Dose-Response Relationship, Drug ; Electrocardiography ; Female ; Geriatrics ; Humans ; Male ; Medical sciences ; Middle Aged ; Nortriptyline - adverse effects ; Nortriptyline - analogs & derivatives ; Nortriptyline - blood ; Nortriptyline - therapeutic use ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>The American journal of psychiatry, 1985-07, Vol.142 (7), p.866-868</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a380t-c4a209b2482337af23cd994cd41c6bbe2b45241ab10c25ca1f1c655a2aaaf7b23</citedby><cites>FETCH-LOGICAL-a380t-c4a209b2482337af23cd994cd41c6bbe2b45241ab10c25ca1f1c655a2aaaf7b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.142.7.866$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.142.7.866$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2846,21608,27846,27901,27902,77534,77535</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8523001$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4014510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOUNG, R. C</creatorcontrib><creatorcontrib>ALEXOPOULOS, G. S</creatorcontrib><creatorcontrib>SHAMOIAN, C. A</creatorcontrib><creatorcontrib>KENT, E</creatorcontrib><creatorcontrib>DHAR, A. K</creatorcontrib><creatorcontrib>KUTT, H</creatorcontrib><title>Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>Among 18 elderly depressed patients given ECGs before and during
nortriptyline treatment, plasma E-10-hydroxynortriptyline and the sum of
E-10-hydroxynortriptyline and nortriptyline distinguished the group with
conduction/repolarization effects. Plasma nortriptyline, age, drug dose,
and baseline cardiovascular status did not.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Arrhythmias, Cardiac - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - physiopathology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nortriptyline - adverse effects</subject><subject>Nortriptyline - analogs & derivatives</subject><subject>Nortriptyline - blood</subject><subject>Nortriptyline - therapeutic use</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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K ; KUTT, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a380t-c4a209b2482337af23cd994cd41c6bbe2b45241ab10c25ca1f1c655a2aaaf7b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Arrhythmias, Cardiac - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - physiopathology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nortriptyline - adverse effects</topic><topic>Nortriptyline - analogs & derivatives</topic><topic>Nortriptyline - blood</topic><topic>Nortriptyline - therapeutic use</topic><topic>Psychology. 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C</au><au>ALEXOPOULOS, G. S</au><au>SHAMOIAN, C. A</au><au>KENT, E</au><au>DHAR, A. K</au><au>KUTT, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>1985-07</date><risdate>1985</risdate><volume>142</volume><issue>7</issue><spage>866</spage><epage>868</epage><pages>866-868</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>Among 18 elderly depressed patients given ECGs before and during
nortriptyline treatment, plasma E-10-hydroxynortriptyline and the sum of
E-10-hydroxynortriptyline and nortriptyline distinguished the group with
conduction/repolarization effects. Plasma nortriptyline, age, drug dose,
and baseline cardiovascular status did not.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>4014510</pmid><doi>10.1176/ajp.142.7.866</doi><tpages>3</tpages></addata></record> |
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language | eng |
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source | Psychiatry Legacy Collection; MEDLINE; Periodicals Index Online |
subjects | Age Factors Aged Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - diagnosis Biological and medical sciences Depressive Disorder - blood Depressive Disorder - drug therapy Depressive Disorder - physiopathology Dose-Response Relationship, Drug Electrocardiography Female Geriatrics Humans Male Medical sciences Middle Aged Nortriptyline - adverse effects Nortriptyline - analogs & derivatives Nortriptyline - blood Nortriptyline - therapeutic use Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
title | Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients |
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