Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients

Among 18 elderly depressed patients given ECGs before and during nortriptyline treatment, plasma E-10-hydroxynortriptyline and the sum of E-10-hydroxynortriptyline and nortriptyline distinguished the group with conduction/repolarization effects. Plasma nortriptyline, age, drug dose, and baseline car...

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Veröffentlicht in:	The American journal of psychiatry 1985-07, Vol.142 (7), p.866-868
Hauptverfasser:	YOUNG, R. C, ALEXOPOULOS, G. S, SHAMOIAN, C. A, KENT, E, DHAR, A. K, KUTT, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - diagnosis Biological and medical sciences Depressive Disorder - blood Depressive Disorder - drug therapy Depressive Disorder - physiopathology Dose-Response Relationship, Drug Electrocardiography Female Geriatrics Humans Male Medical sciences Middle Aged Nortriptyline - adverse effects Nortriptyline - analogs & derivatives Nortriptyline - blood Nortriptyline - therapeutic use Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry
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Zusammenfassung:	Among 18 elderly depressed patients given ECGs before and during nortriptyline treatment, plasma E-10-hydroxynortriptyline and the sum of E-10-hydroxynortriptyline and nortriptyline distinguished the group with conduction/repolarization effects. Plasma nortriptyline, age, drug dose, and baseline cardiovascular status did not.
ISSN:	0002-953X 1535-7228
DOI:	10.1176/ajp.142.7.866